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CAS No. 3144-16-9 | (1S)-(+)-Camphor-10-sulphonic acid

CAS No. 3144-16-9 | (1S)-(+)-Camphor-10-sulphonic acid

Name: (1S)-(+)-Camphor-10-sulphonic acid CAS No. 3144-16-9 MF:C10H16O4S MW:232.3 Purity:98% Package: 10g,25g,50g,100g,250g Worldwide Delivery

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Pharmaceutical Intermediates

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Product introduction

Introduction and application of CAS No. 3144-16-9 | (1S)-(+)-Camphor-10-sulphonic acid

Synonyms:D-CAMPHORSULFONICACID;

D(-)-CAMPHORSULPHONICACID;

D-REYCHLER'SACID;

D-OXO-10-BORNANESULFONICACID;

(+)-BETA-CAMPHORSULFONICACID;

(+)-CAMPHOR-10-SULFONICACID;

(+)-CAMPHOR-10-SULFONICACID(BETA);

(1S)-(+)-CAMPHOR-10-SULFONICACID

Specification:

ITEMS	SPECIFICATION
CAS	3144-16-9
MF	C10H16O4S
MW	232.3
Melting point	196-200 °C
Boiling point	344.46°C
Density	1.2981
Acidity coefficient	1.17±0.50
Color	White to off-white
Solubility	Exhibits moderate solubility in HCl.
Form	crystalline powder
Storage condition	Store below +30°C.

Introduction;

Optically active left- and right-handed camphorsulfonic acid is an important resolving agent for chiral isomer drugs. The dextrorotatory form can be obtained from natural camphor through bromination and sulfonation, or it can be obtained from racemic camphor sulfonic acid through induced crystallization resolution.

preparation:

Preparation and separation of left-handed and right-handed camphorsulfonic acid: In a 100-liter enamel kettle, add 23.2 kg of racemic camphorsulfonic acid, 18 kg of resolving agent composition, and 20 kg of water while stirring, mix and heat to 60 to 100 ℃ for 1 hour, cool to 5~10℃, keep for 1 hour, filter to obtain dextrocamphorsulfonic acid double salt, add 3 times the amount of water, heat to 60~100℃, adjust the pH value to 4~7 with ammonia water, and then Cool to 5-10°C, filter and recover the resolving agent composition. The filtrate is dextrorotary camphorsulfonate ammonium salt solution, and the resolution rate is 99%. The mother liquor from which the double salts are filtered is added to ammonia water to neutralize to pH 4-7, cooled to 5-10°C, and the resolving agent composition is filtered out. The filtrate is L-camphorsulfonate ammonium salt solution, and the resolution rate is 100%. Purification: Put the L-camphorsulfonate ammonium salt solution and D-camphorsulfonate ammonium salt solution into chromatography columns A and B respectively, and slowly collect the L-camphorsulfonate ammonium salt solution in A column and D-camphorsulfonate ammonium salt solution in B column Ammonium sulfonate solution, A and B solutions were evaporated and concentrated in a thin film evaporator until anhydrous, then acetic acid and acetic anhydride solvents were added to crystallize, cooled to 5-25°C, filtered, and dried to obtain white crystals, L-camphorsulfonic acid The optical purity is 99.5%, and the optical purity of dextrorotary camphorsulfonic acid is 99.7%. Chemical Properties: White crystal or crystalline powder, insoluble in ether, slightly soluble in glacial acetic acid and ethyl acetate, easily deliquescent in humid air.

use:

Organic synthesis intermediates, resolving agents, can be used as resolving agents, and catalysts for dipeptide coupling, used for the resolution of pharmaceutical intermediates or isomer products, and used in the pharmaceutical industry

Package and transportation :

Package: 10g,25g,50g,100g,250g